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   The Local Executive Committee [LEC] The Local Executive Committee consists of the Wellstone MD CRC Director, Co-Director, the Project and Core leaders and Office of Patient Communications and Liaison (OPCL). The LEC members are: Dr. Emerson, Dr. Kunkel, Dr. Jeffrey Boone Miller, PI, Dr. Kathryn Wagner, PI, Dr. Robert J. Bloch, PI , Dr. Woodring Wright, Daniel Perez, and Dr. Mayana Zatz. The Local Executive Committee meets at least once monthly. The roles of the LEC are: to maintain the existing collaborations among the principal investigators and their component projects; to foster new collaborations among the projects and determine whether the progress and goals are being met; to oversee the financial accountability and viability of the seven (7) component projects and cores, and, to plan the overall direction of the Wellstone MD CRC, long-term strategies, and new technologies. The Authority of the Director Charles P. Emerson, Jr., Ph.D. : Director The Director of Core A and Wellstone MD CRC is Charles P. Emerson, Jr., Ph.D. Dr. Emerson is a Senior Scientist, and the Director of the Boston Biomedical Research Institute since 2003. He is an internationally recognized developmental biologist for his research on skeletal myogenesis. He has been the recipient of NIH Career Development and Merit Awards and two NIH training grants. Dr. Emerson will serve as the Wellstone MD CRC Director as well as the lead investigator in myoblast cell culture studies to understand the cellular pathology of FSHD in Project 3 and to establish a FSHD myoblast cell repository in Cell Core C. Louis M. Kunkel, Ph.D. : Co-Director The Wellstone MD CRC Co-Director is Dr. Louis M. Kunkel, Ph.D. who is the Director of the Program in Genomics at Children's Hospital, Boston. He is also an Investigator with the Howard Hughes Medical Institute and a Professor of Pediatrics and of Genetics at Harvard Medical School. He is an internationally recognized geneticist with years of experience and scientific success in the understanding of the basis for muscular dystrophies. Over the past three decades, he has devoted his career to understanding the molecular basis of, and developing therapy for neuromuscular disorders. Dr. Kunkel is universally recognized for the identification of the gene and encoded protein, dystrophin, which is mutated in boys with Duchenne/Becker muscular dystrophy, in 1986-1987. He has received 22 awards and honors for scientific leadership and achievement including memberships in the National Academy of Sciences and the American Academy of Arts and Sciences, The Gardner Foundation International Award in 1989, Silvio O. Conte Decade of Brain Award in 1991, the MDS's S. Mouchly Small Scientific Achievement Award 1999, and the William Allan Award for Distinguished Service in Human Genetics in 2004. In addition to serving as Co-Director, Dr. Kunkel is the principal investigator in Project 2: RNA / RNAi profiling studies for FSHD biomarker identification. Responsibilities of the Program Director and Co-Director The Director and Co-Director are responsible for:
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